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Article in English | IMSEAR | ID: sea-163229

ABSTRACT

1KE8 is known as a potential target for anti-cancer medication. Indoles are biologically active nitrogen heterocyclics known for broad spectrum activities. Modification of Indole ring system with selected structural descriptors has offered a high degree of stereo specificity and diversity in activity to the moiety.


Subject(s)
Antineoplastic Agents/pharmacokinetics , Binding Sites , Computer Simulation , Cyclin-Dependent Kinase 8/metabolism , Heterocyclic Compounds, 2-Ring/pharmacokinetics , Indoles/classification , Indoles/pharmacokinetics , Molecular Docking Simulation , Molecular Dynamics Simulation
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